Haha, RobP might have a point. Can't beat tlv for the women.
I don't know j-lem too well as far as nightlife. Last time I went out there (years ago) I met a really hot half american girl at a friend's party. Went back for a date later that week, only to find out she was much more religious than she'd originally let on, and started talking to me about how many babies she wanted - and this was the first date. Obviously ended that date quickly.
And remember the all too true joke - in j-lem, the size of a girl's chest is directly proportionate to how religious she is. in other words, the bigger her breasts, the less likely you're gonna get to see them.
Anyway, I don't wanna knock the city. There's nowhere in the world like it, and it has a cool student scene, though personally it's not a place I'd really want to live. I'll run down the few places I know or have heard of.
Are you Israeli? American? Looking for local girls or foreigners? This will make a difference in where you go.
Link - cool bar / restaurant
Blaze Bar - good live music.
HaOman 17 - this club has been around forever. I had fun in the one in TLV, don't know about the J-lem spot. Maybe good for picking up students?
haTuviya - heard good things about this place. Local spot.
Mike's Place - it's a expat spot, kind of corny, but always plenty of women, and they get a good party going many nights. The girls are easier than other places - either drunk foreign chicks or Israeli women looking to meet foreign guys.
As far as daygame, I never really ran it in j-lem. But did have an easy pickup here once while in the army, described in this thread:
http://www.rooshvforum.network/thread-14304.html
So yeah, if you're in the army, try walking around tourist spots in your Alephs.
Otherwise, I guess the Shuk Machne Yehuda would probably be good for daygame, there's always a ton of people wandering through there with time on their hands.
Since you live there, I guess you already know where NOT to go, but just in case, stay away from Mea Sha'arim, Crack Square, disputed areas, etc.
Hope this is helpful. B'hatzlacha!