[Nemencine]

(01-06-2014 11:30 PM)CaliforniaSupreme Wrote:  

Was reading an article on this earlier. Just the kind of small stock one invests in and makes it big...

indeed. It is a throw of the dice though. it could be a hero or a zero.

(01-06-2014 11:36 PM)elabayarde Wrote:  

good post bro

Thanks, man.

(01-06-2014 11:52 PM)The Lizard of Oz Wrote:  

It's not really a cure yet because the response rates are well short of 100% for some subtypes -- as low as 60% for subtype 3.

But it's clearly a major advance and a big step closer to a cure.

They did a phase 3 test on the viral genotype 1, 2, 3, 4, 5 or 6 and take the test subjects SVR(sustained virological response: which means they look to see if there is still any trace of Hepatitis C virus after 6 months.)

In the case of 1, 4, 5 or 6. ... their SVR clocks in at 89%, 92%, 82% and 96% of test subjects do not have any virus anymore.(neutrino study) The overall SVR is 90%. That is a pretty good number, if you ask me.

In phase 3 study of genotype 2 and 3. the SVR results were 95% of subtype 2, and 56% for subtype 3. (fission study).

So, i guess, pray that you dont get genotype 3 hepatitis C. How many subtype 3 are in the population?

To me these are ridiculously good numbers.

Even analgesic like aspirin never hits 100%....it is ineffective in some people, and some other people the effects are worse, causing analgesic nephropathy.

Sofosbuvir have very negligible side-effects. just nausea, headache, fatigue,etc. nothing to write home about.

(01-07-2014 12:04 AM)Tuthmosis Wrote:  

Time to raw-dogging with impunity:

Can you transmit Hepatitis C through shagging? http://en.wikipedia.org/wiki/Hepatitis_C...ntercourse

(01-07-2014 12:14 AM)kosko Wrote:  

Can we get a Hep primer?

Hep C is purely the one from sex and transfusions? While the others (A and B) come from contaminants but aren't a lifelong illness?

A primer? I will try and get to it later... in the meantime: http://en.wikipedia.org/wiki/Hepatitis_C...ntercourse (through bleeding anal sex. because it is generally transmitted through blood. that is why it was originally seen as "the butt-fucking gay disease")

http://en.wikipedia.org/wiki/Hepatitis_A (Hep A you can get it from contaminated food and shite-stained water in dirty countries or dirty hippies home. hehehehe)

http://en.wikipedia.org/wiki/Hepatitis_B ( Hep B you can get it from pure, regular fucking. but the good news is that your body destroy this Hep B bitch likes its nothing.)

(01-07-2014 12:21 AM)rekruler Wrote:  

Good post, you a bio major as well?

Although to be fair to big pharma, when you pay for a blockbuster drug you're not just paying for the R&D spending it took to develop that one drug, but also for the RD spent on the 100 drugs that failed before they struck gold. Less than 1 out of 100 compounds makes it from the lab to the pharmacy shelves, so when you buy those pills you're not paying for 1 but for 100.

Yes, i studied biochemistry.

on big pharma. you are completely right. another case is the orphan drug status research.

regards,

Nemencine