What I see doesn't seem to be remotely about transgender issues. Note that gender-switching fantasies are common and have nothing to do with any real desire to change gender or even think about the issue of people who do. It seems to me there are several more important angles. I would need more time to think and research this but:
Foremost is the classic idea that super powers correspond with weaknesses, aka
Power At A Price. Cyclops eye weapon can't be controlled without technology. Rogue can't touch people. Iron Man has a synthetic heart and is basically operating a machine. It seems the basic appeal of this show is that the "price" for the power is that you have to become a girl to use it. Which means a boy gets to experience the world through the eyes of a girl while he's in superhero mode. That's the
high concept. This show could have been made decades ago and no one would be flipping out about how it's promoting transgenderism or anything like that. It would have garnered plenty of criticism sure, but cross-dressing in entertainment has been going on for hundreds of years.
Cynically, this means not only does the show have an appealing hook, but it'll attract both boys and girls because the main character is a boy but the superhero appears as a girl. Both genders watching means more viewers and ultimately cash money for the producers.
The problem of course is that appearing to be a girl is actually not much of a weakness at all if the character retains his original personality and has super-human powers. It seems the only thing he has to overcome is his own discomfort about appearing as a girl or coping with how people treat him.
I expect that if I were to have a problem with the show, it'll be if they play up unrealistic discrimination against Shezow for being female.